improvement effect of lycium barbarum polysaccharide on sub-health mice

objective(s):sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. in the present study, we evaluated the effects of lycium barbarum polysaccharide (lbp), a polysaccharide fraction purified from lycium barbarum (l. barbarum) on the sub-health mice. materials and methods:the sub-health model mice were built through compound factors. the mice were given intragastric administration of lbp at low dose (50 mg•kg-1) and high dose (100 mg•kg-1), respectively. after lbp treatment for 4 weeks, the antioxidant ability, enhancing immune function and anti-fatigue activity were detected. results:the results showed that lbp could enhance antioxidant ability in sub-health mice. lbp could effectively improve immunity of sub-health mice and protect the immune organs, such as thymus. in addition, lbp showed anti-fatigue ability in sub-health mice. conclusion:lbp could improve sub-health state caused from composite factor through three aspects, such as increasing antioxidant ability, promoting t lymphocyte proliferation, inhibiting thymus lymphocyte apoptosis, and alleviating fatigue.